Opaleye Management Inc.: insider buys
Every open-market stock purchase reported by Opaleye Management Inc. to the SEC on Form 4.
Total bought$20.02M
Purchases53
Companies4
Last purchase filedOct 26, 2026
Return on these buys+22%
Opaleye Management Inc. has made 53 open-market purchases worth $20.02M in 4 companies since Oct 9, 2025, according to SEC Form 4 filings. The most recent was filed on Oct 26, 2026: 87,801 shares of GRCE at $1.81 (10% Owner), worth $158.60K. The largest was $2.86M of SLGL on Mar 24, 2026. Taken together, these purchases are up 22% at the latest closing prices (split-adjusted, weighted by amount).
Companies Opaleye Management Inc. bought
| Ticker | Company | Role | Buys | Total | Since buy | Last filed |
|---|---|---|---|---|---|---|
| SLGL | Sol-Gel Technologies Ltd. | 10% Owner | 21 | $11.21M | +20% | Sep 14 |
| ACOG | Alpha Cognition Inc. | 10% Owner | 23 | $8.22M | +27% | Oct 26 |
| GRCE | Grace Therapeutics, Inc. | 10% Owner | 8 | $552.56K | -0.4% | Oct 26 |
| SNWV | SANUWAVE Health, Inc. | 10% Owner | 1 | $38.36K | -83% | Oct 9 |
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| Filed | Stock | Insider | Value | Shares | Price | Since buy | Stake | Trade | |
|---|---|---|---|---|---|---|---|---|---|
| Oct 26 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $158.60K | 87,801 | $1.81 | +7.4% | +3% | Oct 22 | SEC |
| Oct 26 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $265.82K | 32,090 | $8.28 | +5.5% | +1% | Oct 22 | SEC |
| Oct 19 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $308.58K | 36,940 | $8.35 | +4.6% | +1% | Oct 15 | SEC |
| Oct 16 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $136.18K | 71,065 | $1.92 | +1.2% | +2% | Oct 14 | SEC |
| Oct 13 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $29.68K | 14,632 | $2.03 | -4.4% | +0% | Oct 8 | SEC |
| Oct 5 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $123.82K | 60,490 | $2.05 | -5.2% | +2% | Oct 1 | SEC |
| Oct 2 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $165.63K | 19,050 | $8.69 | +0.5% | +1% | Oct 1 | SEC |
| Oct 1 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $16.40K | 7,849 | $2.09 | -7.2% | +0% | Sep 29 | SEC |
| Sep 28 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $270.87K | 31,763 | $8.53 | +2.5% | +1% | Sep 24 | SEC |
| Sep 23 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $31.69K | 15,089 | $2.10 | -7.6% | +0% | Sep 21 | SEC |
| Sep 16 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $1.06M | 123,918 | $8.57 | +1.9% | +4% | Sep 14 | SEC |
| Sep 14 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $207.41K | 3,124 | $66.39 | +2.9% | +1% | Sep 10 | SEC |
| Sep 10 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $31.92K | 15,229 | $2.10 | -7.5% | +1% | Sep 8 | SEC |
| Sep 9 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $687.17K | 9,976 | $68.88 | -0.8% | +2% | Sep 4 | SEC |
| Sep 3 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $116.49K | 1,683 | $69.22 | -1.3% | +0% | Sep 1 | SEC |
| Aug 31 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $2.79M | 40,330 | $69.19 | -1.2% | +8% | Aug 28 | SEC |
| Aug 19 | GRCEGrace Therapeutics, Inc. | Opaleye Management Inc.10% Owner | $24.26K | 11,608 | $2.09 | -7.2% | +0% | Aug 14 | SEC |
| Aug 14 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $68K | 951 | $71.50 | -4.4% | +0% | Aug 12 | SEC |
| Aug 4 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $422.97K | 52,900 | $8.00 | +9.3% | +2% | Jul 31 | SEC |
| Jul 24 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $1.57M | 200,086 | $7.82 | +12% | +7% | Jul 22 | SEC |
| Jul 15 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $124.82K | 1,695 | $73.64 | -7.2% | +0% | Jul 13 | SEC |
| Jul 10 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $39.04K | 529 | $73.80 | -7.4% | +0% | Jul 8 | SEC |
| Jul 2 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $123.22K | 1,712 | $71.97 | -5.0% | +0% | Jul 1 | SEC |
| Jun 29 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $976.23K | 152,533 | $6.40 | +37% | +6% | Jun 25 | SEC |
| Jun 15 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $45.79K | 7,685 | $5.96 | +47% | +0% | Jun 11 | SEC |
| Jun 11 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $183.81K | 30,728 | $5.98 | +46% | +1% | Jun 9 | SEC |
| Jun 9 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $58.61K | 10,054 | $5.83 | +50% | +0% | Jun 5 | SEC |
| May 29 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $434.72K | 73,738 | $5.90 | +48% | +3% | May 27 | SEC |
| May 22 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $100.70K | 1,563 | $64.43 | +6.1% | +0% | May 20 | SEC |
| May 22 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $140.55K | 24,376 | $5.77 | +52% | +1% | May 20 | SEC |
| May 19 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $196.04K | 34,043 | $5.76 | +52% | +1% | May 15 | SEC |
| May 14 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $231.50K | 3,437 | $67.35 | +1.5% | +1% | May 12 | SEC |
| Mar 31 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $60.03K | 11,850 | $5.07 | +73% | +0% | Mar 27 | SEC |
| Mar 26 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $108.62K | 20,082 | $5.41 | +62% | +1% | Mar 24 | SEC |
| Mar 24 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $2.86M | 39,665 | $72.00 | -5.1% | — | Mar 24 | SEC |
| Mar 20 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $26.22K | 4,575 | $5.73 | +52% | +0% | Mar 18 | SEC |
| Mar 13 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $75.70K | 13,066 | $5.79 | +51% | +0% | Mar 12 | SEC |
| Mar 10 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $23.77K | 4,079 | $5.83 | +50% | +0% | Mar 6 | SEC |
| Mar 6 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $387.74K | 66,818 | $5.80 | +51% | +3% | Mar 4 | SEC |
| Mar 4 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $411.61K | 71,411 | $5.76 | +52% | +3% | Mar 2 | SEC |
| Mar 2 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $25.33K | 4,228 | $5.99 | +46% | +0% | Feb 26 | SEC |
| Feb 24 | ACOGAlpha Cognition Inc. | Opaleye Management Inc.10% Owner | $1M | 171,410 | $5.86 | +49% | — | Feb 20 | SEC |
| Feb 18 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $18.33K | 291 | $63.00 | +8.5% | +0% | Feb 13 | SEC |
| Jan 23 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $187.36K | 3,324 | $56.37 | +21% | +1% | Jan 22 | SEC |
| Jan 6 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $108.87K | 2,592 | $42.00 | +63% | +1% | Jan 2 | SEC |
| Dec 31 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $2.78M | 66,304 | $41.97 | +63% | +21% | Dec 29 | SEC |
| Dec 29 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $120.54K | 2,905 | $41.49 | +65% | +1% | Dec 22 | SEC |
| Dec 19 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $110.41K | 2,735 | $40.37 | +69% | +1% | Dec 17 | SEC |
| Dec 9 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $29.47K | 744 | $39.61 | +73% | +0% | Dec 5 | SEC |
| Dec 3 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $257.62K | 6,864 | $37.53 | +82% | +2% | Dec 1 | SEC |
| Nov 26 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $37.93K | 949 | $39.97 | +71% | +0% | Nov 24 | SEC |
| Nov 21 | SLGLSol-Gel Technologies Ltd. | Opaleye Management Inc.10% Owner | $207.24K | 5,784 | $35.83 | +91% | +2% | Nov 20 | SEC |
| Oct 9 | SNWVSANUWAVE Health, Inc. | Opaleye Management Inc.10% Owner | $38.36K | 1,267 | $30.28 | -83% | +0% | Oct 6 | SEC |